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刘晓军


研究方向:2型糖尿病分子病理机制研究和药物筛选


介绍:刘晓军,男,研究员,博士研究生导师。主要从事2型糖尿病分子病理机制研究和药物筛选。参与研究的项目《中国人2型糖尿病易感基因生物学功能及作用机制的研究》获2008年中华医学科技奖三等奖。2011年获北京协和医学院人才发展规划协和新星资助。2011年获医科院基础所先进科研工作者称号。国家自然科学基金,北京市自然科学基金评审专家。Cell ProliferationPlos One等杂志审稿专家。发表学术论文30余篇。


联系方式:Email: xiaojunliu@ibms.apfhnbc.com      Tel: 010-69156424


代表性论文: (* Corresponding author)

(1) Gao M, Zhao W, Li C, Xie X, Li M, Bi Y, Fang F, Du Y*, Liu X*. Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK.  2018 Oct 20;505(1):93-98. doi: 10.1016/j.bbrc.2018.09.078. Epub 2018 Sep 18.

(2) Geng C, Xu H, Zhang Y, Gao Y, Li M, Liu X, Gao M, Wang X, Liu X*, Fang F*, Chang Y*. Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1. Sci China Life Sci. 2017 Nov;60(11):1234-1241. doi: 10.1007/s11427-016-9027-6. Epub 2017 Jun 29.

(3) Yang YG, Li MX, Kou L, Zhou Y, Qin YW, Liu XJ*, Chen Z*.  Biomed Environ Sci. 2016 Oct;29(10):713-723.

(4) Zhang Y, Geng C, Liu X, Li M, Gao M, Liu X*, Fang F*, Chang Y*. Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1. Mol Metab. 2016 Nov 17;6(1):138-147. doi: 10.1016/j.molmet.2016.11.002. eCollection 2017 Jan.

(5) Geng C, Zhang Y, Gao Y, Tao W, Zhang H, Liu X*, Fang F*, Chang Y*. Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice. Biochem Biophys Res Commun. 2016 Mar 18;471(4):444-9. doi: 10.1016/j.bbrc.2016.02.059. Epub 2016 Feb 20.

(6) Liu X*, Gao Y, Li M, Geng C, Xu H, Yang Y, Guo Y, Jiao T, Fang F*, Chang Y*. Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet. J Hepatol. 2015 Sep;63(3):713-21. doi: 10.1016/j.jhep.2015.05.018. Epub 2015 May 27.

(7) Liu X*, Cui Y, Li M, Xu H, Zuo J, Fang F*, Chang Y*. Cobalt protoporphyrin induces HO-1 expression mediated partially by FOXO1 and reduces mitochondria-derived reactive oxygen species production. PLoS One. 2013 Nov 8;8(11):e80521. doi: 10.1371/journal.pone.0080521. eCollection 2013.

(8) Liu X, Qiao A, Ke Y, Kong X, Liang J, Wang R, Ouyang X, Zuo J, Chang Y, Fang F. FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells. FEBS Lett. 2010 Oct 22;584(20):4330-4. doi: 10.1016/j.febslet.2010.09.027. Epub 2010 Sep 23.

(9) Liu X, Feng Q, Chen Y, Zuo J, Gupta N, Chang Y, Fang F. Proteomics-based identification of differentially-expressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients. J Proteome Res. 2009 Mar;8(3):1255-62. doi: 10.1021/pr800850a.

(10) Liu XJ, Yang C, Gupta N, Zuo J, Chang YS, Fang FD.  J Mol Med (Berl). 2007 Aug;85(8):851-61. Epub 2007 Jul 10.